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KMID : 0604520140400010045
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Journal of the Society of Cosmetic Scientists of Korea
2014 Volume.40 No. 1 p.45 ~ p.54
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Anti-Inflammatory Effects of the Mixture of Sorbus commixta, Urtica dioica, Phyllostachysnigra, and Rhus semialata Gall Extracts on LPS-induced Inflammation in HaCaT Cells
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Lee Kyung-Eun
Nam Jin-Ju
Kim Seon-Mi
Kim Han-Kon
Moon Seong-Joon
Youm Jong-Kyung
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Abstract
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Lipopolysaccharide (LPS)-induced inflammatory responses in the HaCaT keratinocyte cell line produce proinflammatorycytokines, such as interleukin-1α(IL-1α), tumor neurosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) and also increase the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2),and prostaglandins E2 (PGE2). In this study, we developed new natural ingredients for cosmetics that inhibit the pro-inflammatoryresponses induced by LPS in HaCaT cells. The mixture of Sorbus commixta (SC), Urtica dioica (UD),Phyllostachys nigra (PN), and Rhus semialata gall (RS) extracts blocked the increase of TNF-α IL-1α IL-6, and IL-8.The increase of COX-2, iNOS, and PGE2 were also blocked by it. Finally, the mixture inhibited skin irritation inducedby sodium lauryl sulfate (SLS), when applied on skin through IQ chamberⓡ. In conclusion, these results show that themixture of SC, UD, PN, and RS can be used as a primary ingredient to alleviate skin irritation when cosmeceuticalproducts are developed for sensitive skin.
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KEYWORD
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anti-inflammation, skin irritation, pro-inflammatory cytokine, iNOS, PGE2
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